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Plasmid DNA Manufacturing Market Size, Trends, SWOT, PEST, Porter’s Analysis, For 2035

Plasmid DNA Manufacturing Market Overview

In recent years, plasmid DNA service providers are focused on widening their capabilities to offer multiple grades of plasmid DNA in order to meet the growing demand across various pharmaceutical applications, including basic research, drug discovery studies, as well as clinical and commercial applications.

The global plasmid DNA manufacturing market size is estimated to grow from USD 102 million in 2023 to USD 539 million by 2035, representing a CAGR of 14.85% during the forecast period 2023-2035.

In fact 45% of the players offer both GMP plasmid manufacturing as well as research grade plasmid manufacturing services. 40% of the companies engaged in this domain have the capabilities to operate at all three scale of operation. Examples of such firms include (in alphabetical order, large and very large firms based in US) AGC Biologics, Ajinomoto Bio-Pharma Services, Aldevron (acquired by Danaher), Catalent Pharma Solutions, Charles River and GenScript ProBio (a Subsidiary of GenScript). This is followed by those capable of operating at preclinical scale which are about 30%.

The increasing traction in the field of plasmid DNA manufacturing is evident from number of deals inked by the players in the recent past. The number of partnerships inked related to plasmid DNA has increased significantly at a CAGR of 28%, between 2015-2022. It is worth mentioning that 25% of the partnerships were recorded in 2022. Specifically, the rise in partnership activity can be attributed to an increase in the number of clinical trials being conducted to evaluate cell and gene therapies. Further, 83% inked within the domain were signes with industry players.

Majority of the intercontinental, as well as intracontinental partnerships in this domain have been signed by players based in North America which accounts for about 84%. Further, a considerable share of intracontinental agreements was inked by players based in Europe.

Plasmid DNA Manufacturing Market Segmentation

Plasmid DNA Manufacturing Market segments include Distribution by Scale of Operation (Commercial, Clinical and Preclinical), Application Area (Cell Therapy Manufacturing, Gene Therapy Manufacturing, DNA / RNA Vaccine Development, Viral Vector Manufacturing, and Other Application Areas), Therapeutic Area (Metabolic Disorders, Neurological Disorders, Oncological Disorders, Rare Disorders, and Other Disorders), and Geography (North America, Europe, Asia, Latin America, Middle East and North Africa, and Rest of the World). Moreover, in terms of intercontinental collaborations, the majority of the deals were instances wherein a player based in North America entered into an agreement with a company having headquarters in Europe.

 In order to expand their plasmid DNA manufacturing portfolio and gain access to emerging technologies companies are increasingly opting to acquire other players in the industry.

Leading Key Players in the Plasmid DNA Manufacturing Market

Key players in plasmid DNA manufacturing market are AGC Biologics, Aldevron, Biomay, Catalent Pharma Solutions, Charles River, Cytovance Biologics, Forge Biologics, GenScript ProBio, Thermo Fisher Scientific, and VGXI. Multiple instances of acquisitions of various stakeholders involved in the plasmid DNA domain by other players in order to strengthen latter’s service portfolio, during the time period, 2015-2023.

The field of plasmid DNA has witnessed significant consolidation activity in the past few years. This can be attributed to the rise in competition within this domain, which has further compelled the service providers to diversify their portfolios through acquisitions. It is worth mentioning that the acquisition activity has increased at a CAGR of 35%, during the period 2015-2022.

Additionally, it has been observed that several big pharma players have entered this domain through the acquisition of niche service providers. For instance, Sartorius acquired PolyPlus (March 2023). Other examples of big pharma players that have acquired companies focused on plasmid DNA include (in alphabetical order) Catalent, Charles River, Danaher, Thermo Fisher Scientific, WACKER, and WuXi Advanced Therapies (WuXi ATU).

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